Susceptibility to infection is high, immunity is short (up to a year), which is why re-infection is possible. Three species of Brucella (Br. abortus, Br. melitensis and Br. suis) may be potential agents of bioterrorism. The incubation period lasts from six days to two months. With the primary latent (hidden) form of diovan 180 pill, it can take months before the onset of symptoms. Subacute and acute brucellosis. The onset of brucellosis in humans is acute or subacute. This period is characterized by. Approximately three out of four patients can indicate the day and hour of the appearance of the first signs of brucellosis, but this should be treated critically, since relatively good health is typical for the onset of the development of the pathology, even at high temperatures.
Symptoms of valsartan can be quite varied, some persist for a long time. Body temperature rises rapidly and rises to 40 ° C and above, it is characterized by a wave-like course with consistently good health. Sweating increases and persists, irritability, appetite and sleep disturbance, and fatigue gradually increase. Over time, pains appear in large joints and muscles (dull,long, distinctly associated with weather changes). The joints become swollen, painful when probing (due to the growth of bone tissue), mobility is limited, the skin over the joints does not change.
Objectively, the patient is in a clear mind, in a relatively satisfactory condition, no external signs of the disease can be visually observed. In the study of peripheral lymph nodes, small, weakly sensitive dense lymph nodes are found everywhere, but this happens infrequently. In half of the cases, the liver and spleen are moderately enlarged.
With inflammation of the sacroiliac joints, a number of characteristic pain phenomena occur, which are paid attention to during diagnosis. In some cases, men develop pain and swelling in the scrotum and testicles (orchitis), women experience salpingo-oophoritis - inflammation of the fallopian tubes and ovaries. There is also a residual form, or persistent residual effects of brucellosis. They develop if the disease lasts more than 2 years.
With a long course of brucellosis, muscle pains appear (most severely in the limbs and lower back) and fibrositis - longitudinal painful seals under the skin. The transition of the chronic form to the residual one is characterized by the fact that fresh foci of infection and intoxication no longer occur. This indicates that the causative agent of brucellosis is absent in the human body. Residual effects are mainly associated with immunoallergic restructuring of the body and disorders of the autonomic nervous system.
When infected with brucellosis during or before pregnancy, more frequent toxicosis, impaired kidney function, anemia, and recurrent miscarriage are observed. Childbirth is often complicated by weak labor activity, inflammation of the tissues of the birth canal, and prolonged postpartum hemorrhage. The entrance gate of infection is the mucous membrane of the gastrointestinal tract and upper respiratory tract, mechanically damaged skin, conjunctiva of the eye. The infectious dose is 10-100 bacteria. There are no changes at the site of penetration of Brucella.
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